MARKET

CBIO

CBIO

Catalyst Biosciences
NASDAQ

Real-time Quotes | Nasdaq Last Sale

5.50
+0.25
+4.76%
After Hours: 5.69 +0.19 +3.45% 16:13 10/23 EDT
OPEN
5.27
PREV CLOSE
5.25
HIGH
5.54
LOW
5.19
VOLUME
130.99K
TURNOVER
--
52 WEEK HIGH
8.94
52 WEEK LOW
3.430
MARKET CAP
121.35M
P/E (TTM)
-1.6040
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Seekingalpha · 5d ago
Hedge Funds Are Getting Crazy About Catalyst Biosciences Inc (CBIO)
We know that hedge funds generate strong, risk-adjusted returns over the long run, which is why imitating the picks that they are collectively bullish on can be a profitable strategy for retail investors. With billions of dollars in assets, professional investors have to conduct complex analyses, spend many resources and use tools that are not […]
Insider Monkey · 10/15 02:17
Raymond James Says These 3 Stocks Could Surge Over 100% From Current Levels
Election day is just around the corner, and Wall Street is placing its bet on a Democratic sweep. Following the Presidential debate on September 29, the chance of a Biden victory has been increasing in the market.Since September 30, the S&P 500 has moved 5.5% higher. That said, the rotation into cyclicals and small-caps has been much more pronounced, with the Russell 2000 surging 8.5% over the same period.Weighing in for Raymond James, strategist Tavis McCour argues the shift into cyclicals and small-caps “provides some evidence of how the market will rotate in the case of a Democratic sweep, with the logic being stronger fiscal support, steeper yield curve and faster cyclical recovery.”McCour points out that “in the background is remarkably sustainable economic data, and the likely positive impact to EPS.” According to the strategist, Atlanta Fed GDPNow, a model used to estimate real GDP, has increased materially since July, with the firm’s analysts continuing to skew towards raising 2020 EPS estimates nearly every week since May. He noted, “Every sector of the S&P 500 has seen 2020 EPS expectations increase since mid-August (which is not normal). It should be a good Q3 earnings season, and earnings still matter.”Bearing this in mind, our focus turned to three stocks backed by Raymond James, with the firm’s analysts noting that each could skyrocket over 100% from current levels. Running the tickers through TipRanks’ database, we found out that the rest of the Street is also on board, as each boasts a “Strong Buy” consensus rating.Catalyst Biosciences (CBIO)Focused on addressing unmet needs in rare hemostasis and complement-mediated disorders, Catalyst Biosciences hopes to improve the lives of patients from all over the world. Based on the progress of its development pipeline, Raymond James believes its $4.80 share price could reflect the ideal entry point.After the company provided an update on the recent progress made by both of its lead assets gearing up for Phase 3, MarzAA and DalcA, firm analyst David Novak points out that his bullish thesis is very much intact. MarzAA is a next-generation SQ FVIIa designed as a potential treatment for hemophilia A or B with inhibitors, and DalcA is an SQ FIX designed for hemophilia B.“With two Phase 3-ready assets addressing a significant market opportunity and shares currently trading at an enterprise value of ~$2 million, CBIO remains substantially undervalued in our view. We believe the company is well-positioned for a significant market re-rating over the next 12 months,” Novak commented.Highlighting its poster presentations at the International Society for Thrombosis and Haemostasis (ISTH) Virtual Congress, Novak believes the data supports the selected dosing regimen for MarzAA in the upcoming Phase 3 CRIMSON-1 trial. On top of this, strong safety and efficacy data from its Phase 2b trial of DalcA was presented at the World Federation of Hemophilia Virtual Summit.To this end, Novak sees several potential catalysts on the horizon. The enrollment of the first patient in the Phase 3 trial of MarzAA in hemophilia A or B with inhibitors is slated for 2H20, but this is subject to COVID-related delays. What’s more, MarzAA will be evaluated in a Phase 1/2 trial in patients with FVII deficiency, Glanzmann Thrombastenia and those using Hemlibra, with this trial set to kick off in late 2020.Adding to the good news, the announcement of a FIX gene therapy candidate and the unveiling of a systemic complement inhibitor development candidate, which could both come in late 2020, stand to drive additional upside, in Novak’s opinion.To this end, Novak rates CBIO an Outperform (i.e. Buy) along with a $20 price target. Investors could be pocketing a massive gain of 317%, should this target be met in the twelve months ahead. (To watch Novak’s track record, click here)Other analysts don’t beg to differ. With 3 Buy ratings and no Holds or Sells, the word on the Street is that CBIO is a Strong Buy. At $19.33, the average price target implies 303% upside potential from current levels. (See CBIO stock analysis on TipRanks)Mirum Pharmaceuticals (MIRM)With the goal of creating life-changing therapies for patients with liver diseases, Mirum Pharmaceuticals believes its approach can address the underlying causes. Ahead of a key filing, Raymond James likes what it has been seeing.Writing for the firm, 5-star analyst Steven Seedhouse points out that his optimism is driven by MIRM’s new plan to submit an MAA application to the European Medicines Agency (EMA) for maralixibat (MRX), its minimally absorbed and orally administered investigational therapy that could potentially be used in several indications, in PFIC2 in Q4 2020.While this filing would come before the ongoing MARCH Phase 3 study wraps up, Seedhouse points out that this move is in line with discussions it has already had with the EMA. According to the analyst, based on statistical analyses conducted by NAPPED that compared Phase 2 data (including long-term transplant-free survival data) to natural history data, the EMA is on board with MIRM’s strategy to file for full approval.“Thus, we have increased confidence MRX will be approved in PFIC2, which we estimate could occur by Q1 2022 (up from our estimate of 2H22),” Seedhouse mentioned. Contributing to his bullish stance, MRX already has a very large safety database as it has been evaluated in several studies across multiple indications (NASH, ALGS and PFIC).Additionally, the Phase 2 INDIGO study demonstrated a statistically significant pruritus improvement (ItchRO scale) in the overall PFIC2 population, as well as strong and sustained improvements in serum bile acid (sBA) level, ItchRO score, height z-score and PedsQL (quality of life metric) for 6 responder patients that all had a form of the disease characterized by non-truncating bile salt export pump (BSEP) protein. Approximately half of all PFIC patients fall into this category.Looking at data on five-year outcomes with MRX, transplant-free survival was established in seven non-truncating PFIC2 patients who achieved sBA control. If that wasn’t enough, no clinical events were witnessed and 2 out of 7 patients came off of the transplant waiting list.Seedhouse added, “This data is further supported by natural history data from the NAPPED consortium, which shows 100% 15-year native liver survival in biliary diversion patients with sBA levels controlled to below 102µmol/L.”Everything that MIRM has going for it convinced Seedhouse to put a Strong Buy rating on the stock. He assigned a $48 price target, suggesting 140% upside potential. (To watch Seedhouse’s track record, click here)Are other analysts in agreement? They are. Only Buy ratings, 5 to be exact, have been issued in the last three months. Therefore, the message is clear: MIRM is a Strong Buy. Given the $49.50 average price target, shares could soar 150% in the next year. (See MIRM stock analysis on TipRanks)PolyPid (PYPD)Last but not least we have PolyPid, which develops locally administered therapies to improve surgical outcomes. Given the strength of its PLEX (Polymer-Lipid Encapsulation matriX) technology, which is a platform that is anchored in the surgical site to provide controlled and continuous delivery of medications, Raymond James thinks that it's time to get in on the action.The company only IPO’d in June, and it has already impressed firm analyst Elliot Wilbur. Looking at its D-PLEX100 product, it was granted Fast Track Designation by the FDA for the prevention of post abdominal surgical site infections (SSIs) in August. Fast Track Designation gives PYPD an advantage in that it increases the frequency of communication with the FDA. Additionally, it enables a rolling submission of the NDA, which allows the company to submit parts of the application as they are completed, expediting the review process.“Although earlier approval is not guaranteed with the Fast Track Designation, the additional resources available to the company and the FDA recognition that D-PLEX100 has potential to address the unmet medical needs of the SSI market should be viewed as positives,” Wilbur stated.In July, PYPD enrolled the first patient in its randomized SHIELD I (Surgical site Hospital acquired Infection prEvention with Local D-plex) trial, the first of two Phase 3 clinical trials evaluating D-PLEX100 in post-abdominal surgery (soft tissue) SSIs. The primary endpoint is prevention of deep or superficial surgical site infection, as determined by a blinded review committee within 30 days post abdominal surgery.Wilbur expects the application of D-PLEX100 locally to the wound site combined with its extended release through thousands of bilayers of polymers and lipids to yield increased efficacy and safety over the current standard of care (SoC), which usually involves an antibiotic IV before an incision.It should be noted that SHIELD I remains on track to enroll 600-900 patients across 60 centers globally, starting with centers in Israel and Europe before continuing to the U.S. “Management sees minimal anticipated impacts from the COVID-19 pandemic for this trial, and robust top line data (expected in late 2021) coupled with the benefits from the Fast Track Designation may be enough to obtain early approval for the drug,” Wilbur commented.As SHIELD II is set to initiate in late 2020, with it serving as the second potential confirmatory Phase 3 trial, Wilbur sees an exciting opportunity on the table.It should come as no surprise, then, that Wilbur sides with the bulls. In addition to an Outperform rating, he, the price target is left at $23, indicating 128% upside potential. (To watch Wilbur’s track record, click here)What does the rest of the Street have to say? Other analysts echo Wilbur’s sentiment. PYPD’s Strong Buy consensus rating breaks down into 4 Buys and no Holds or Sells. With an average price target of $25.50, the upside potential comes in at 153%. (See PYPD stock analysis on TipRanks)To find good ideas for stocks trading at attractive valuations, visit TipRanks’ Best Stocks to Buy, a newly launched tool that unites all of TipRanks’ equity insights.Disclaimer: The opinions expressed in this article are solely those of the featured analysts. The content is intended to be used for informational purposes only. It is very important to do your own analysis before making any investment.
TipRanks · 10/14 14:29
Catalyst Bio secures US patent for engineered proteases
United States Patent and Trademark Office has issued a U.S. patent to Catalyst Biosciences (CBIO) patent no. 10,781,435 B2, covering its portfolio of engineered proteases that selectively cleave and degrade complement
Seekingalpha · 10/14 12:36
Catalyst Biosciences Receives US Patent For Its Anti-Complement Factor 3 Portfolio Of Engineered Proteases
SOUTH SAN FRANCISCO, Calif., Oct. 14, 2020 (GLOBE NEWSWIRE) -- Catalyst Biosciences, Inc. (NASDAQ:CBIO) today announced that the United States Patent and Trademark Office (USPTO) has issued US Patent Number 10,781,435 B2
Benzinga · 10/14 12:04
Catalyst Biosciences Receives US Patent for its Anti-Complement Factor 3 Portfolio of Engineered Proteases
CB 2782-PEG patent protection extended until at least 2038SOUTH SAN FRANCISCO, Calif., Oct. 14, 2020 (GLOBE NEWSWIRE) -- Catalyst Biosciences, Inc. (NASDAQ: CBIO) today announced that the United States Patent and Trademark Office (USPTO) has issued US Patent Number 10,781,435 B2 entitled “Modified Membrane Type Serine Protease 1 (MTSP-1) Polypeptides and Methods of Use.” This patent covers Catalyst’s portfolio of engineered proteases that selectively cleave and degrade complement factor 3 (C3), including the lead candidate CB 2782-PEG, a potential best-in-class treatment for dry AMD currently partnered with Biogen. These modified proteases inhibit complement activation and have the potential to treat multiple diseases in which dysregulated complement activation plays a role. The newly issued patent provides protection until at least 2038. “CB 2782 demonstrates the power of our protease engineering platform and focus on the complement cascade. We plan to leverage our platform to expand the number of candidates we move into clinical development over the coming years,” said Nassim Usman, Ph.D., president and chief executive officer of Catalyst Biosciences.About Catalyst Biosciences Catalyst is a research and clinical development biopharmaceutical company focused on addressing unmet needs in rare hematologic and complement-mediated disorders. Our protease engineering platform includes two late-stage clinical programs in hemophilia; a research program on engineering of subcutaneous (SQ) complement inhibitors; and a partnered preclinical development program with Biogen for dry age-related macular degeneration (AMD). The product candidates generated by our protease engineering platform have improved functionality and potency that allow for: SQ administration of recombinant coagulation factors and complement inhibitors; low-dose, high activity gene therapy constructs; and less frequently dosed intravitreal therapeutics. Our most advanced product candidate is marzeptacog alfa (activated) (MarzAA), a next-generation SQ FVIIa entering a Phase 3 registration study in late 2020. Our next late-stage product candidate is dalcinonacog alfa (DalcA), a next-generation SQ FIX, which has demonstrated efficacy and safety in a Phase 2b clinical trial in individuals with Hemophilia B. We have a discovery stage Factor IX gene therapy construct - CB 2679d-GT - for Hemophilia B, that has demonstrated superiority compared with the Padua variant in preclinical models. Finally, we have a global license and collaboration agreement with Biogen for the development and commercialization of anti-complement Factor 3 (C3) pegylated CB 2782.Forward-Looking Statements This press release contains forward-looking statements that involve substantial risks and uncertainties. Forward-looking statements include statements about Catalyst’s plans to move new product candidates into clinical development in the coming years, the potential benefits of products based on Catalyst’s engineered protease platform, plans to enroll the first patient into a Phase 3 registration study of MarzAA in late 2020, the potential for MarzAA and DalcA to effectively and therapeutically treat hemophilia subcutaneously, the superiority of CB 2679d-GT over other gene therapy candidates and the Company’s collaboration with Biogen for the development and commercialization of pegylated CB 2782 for the potential treatment of geographic atrophy-associated dry age-related macular degeneration. Actual results or events could differ materially from the plans, intentions, expectations and projections disclosed in the forward-looking statements. Various important factors could cause actual results or events to differ materially, including, but not limited to, the risk that trials and studies may be delayed as a result of the COVID-19 virus and other factors, that trials may not have satisfactory outcomes, that additional human trials will not replicate the results from earlier trials, that potential adverse effects may arise from the testing or use of DalcA or MarzAA, including the generation of neutralizing antibodies, which has been observed in patients treated with DalcA, the risk that costs required to develop or manufacture the Company’s products will be higher than anticipated, including as a result of delays in development and manufacturing resulting from COVID-19 and other factors, the risk that Biogen will terminate Catalyst’s agreement, competition and other risks described in the “Risk Factors” section of the Company’s quarterly report filed with the Securities and Exchange Commission on August 6, 2020, and in other filings with the Securities and Exchange Commission. The Company does not assume any obligation to update any forward-looking statements, except as required by law.Contact:Ana Kapor Catalyst Biosciences, Inc. investors@catbio.com
GlobeNewswire · 10/14 12:00
We Think Catalyst Biosciences (NASDAQ:CBIO) Can Afford To Drive Business Growth
Even when a business is losing money, it's possible for shareholders to make money if they buy a good business at the...
Simply Wall St. · 10/07 11:46
39% of working parents fear they'll be fired if they take advantage of child-care benefits at work
Amid layoffs and a recession spurred by the coronavirus pandemic, many working parents say they don't want to rock the boat with their employers right now — even if it means forgoing workplace benefits they're entitled to use. 
CNBC.com · 09/25 13:00
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Analyst Rating

Based on 4 analysts

Buy

Disclaimer: The analysis information is for reference only and does not constitute an investment recommendation.

Analyst Price Target
The average CBIO stock price target is 20.25 with a high estimate of 23.00 and a low estimate of 18.00.
EPS
Institutional Holdings
Institutions: 109
Institutional Holdings: 16.11M
% Owned: 73.02%
Shares Outstanding: 22.06M
TypeInstitutionsShares
Increased
22
2.45M
New
37
1.79M
Decreased
15
972.12K
Sold Out
0
0
  • Performance
  • Asset Allocation
  • Dividend History
No Data
Industry
Biotechnology & Medical Research
+0.56%
Pharmaceuticals & Medical Research
+0.69%
Key Executives
Chairman/Independent Director
Augustine Lawlor
President/Chief Executive Officer/Director
Nassim Usman
Chief Financial Officer
Clinton Musil
Senior Vice President
Charles Democko
Other
Howard Levy
Vice President
Arwa Shurrab
Independent Director
Errol De Souza
Independent Director
Andrea Hunt
Other
Jamie Siegel
Independent Director
Geoffrey Ling
Independent Director
Sharon Tetlow
Independent Director
Edward Williams
Independent Director
Fei Ling Shiu
  • Dividends
  • Splits
  • Insider Activity
Declaration Date
Dividend Per Share
Ex-Div Date
08/04/2015
Dividend USD 0.5692
08/20/2015
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About CBIO
Catalyst Biosciences, Inc., formerly Targacept, Inc., is a clinical-stage biopharmaceutical company. The Company is focused on creating and developing medicines to address serious medical conditions. The Company focuses its product development efforts in the fields of hemostasis, including the treatment of hemophilia and surgical bleeding, and inflammation, including prevention of delayed graft function (DGF) in renal transplants and the treatment of dry age-related macular degeneration (dry AMD), a condition that can cause visual impairment or blindness. The Company's advanced program is a coagulation Factor VIIa variant, CB 813d, that has completed a Phase I clinical trial in severe hemophilia A and B patients. In addition to its lead Factor VIIa program, it has approximately two other coagulation factors, a Factor IX variant, CB 2679d/ISU 304, that is in advanced preclinical development, and a Factor Xa variant that has reached the advanced lead preclinical-stage of development.
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