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Akari Therapeutics (NASDAQ:AKTX) Will Have To Spend Its Cash Wisely
We can readily understand why investors are attracted to unprofitable companies. For example, biotech and mining...
Simply Wall St. · 22h ago
The Daily Biotech Pulse: Novartis Acquires Gene Therapy Company, Moderna's Japanese Vaccine Supply Deal
Here's a roundup of top developments in the biotech space over the last 24 hours. Scaling The Peaks (Biotech Stocks Hitting 52-week Highs Oct. 28)
Benzinga · 10/29 11:30
Akari Therapeutics to Present Phase II Data from Bullous Pemphigoid Trial at European Academy of Dermatology and Venereology (EADV) Virtual Congress October 29
* Safety and efficacy data from Phase II clinical trial of nomacopan in adults with mild to moderate BP * The Phase II data was the basis for the agreement of the FDA and the EMA that Akari may proceed to a Phase III randomised placebo-controlled study using nomacopan for treatment of BP * Phase III study in both the U.S. and Europe expected to begin in H1 2021 * Nomacopan has been granted orphan drug designation for treatment of BP in the U.S. and EuropeNEW YORK and LONDON, Oct. 27, 2020 (GLOBE NEWSWIRE) -- Akari Therapeutics, Plc (Nasdaq: AKTX), a biopharmaceutical company focused on innovative therapeutics to treat orphan autoimmune and inflammatory diseases where the complement and/or leukotriene systems are implicated, today announces that it will be presenting a poster during the 29th European Academy of Dermatology and Venereology (EADV) Congress being held virtually October 28 – November 1, 2020. The presentation will be posted onto Akari’s website.The poster presentation will describe the safety and efficacy data from Akari’s Phase II clinical trial of nomacopan in adult patients with mild to moderate bullous pemphigoid.Details of the presentation are as follows: * Title: A Phase II Clinical Trial of Safety and Efficacy of Nomacopan (rVA576) in Adult Mild-to-moderate Bullous Pemphigoid Patients * Date/Time: October 29, 2020 at 12:00 CET (7:00 a.m. EDT) * Location: EADV Virtual Meeting. Registration is required to participate: About Bullous Pemphigoid (BP) BP is a severe orphan autoimmune inflammatory blistering skin disease with no approved treatments in the U.S. and Europe. This disease of the elderly is primarily treated with steroids and immunosuppressants for six months plus which bring with them deleterious side effects and an approximately three-fold increase in mortality in the BP treated population. The prevalence of BP is over 100,000 patients in US and Europe.In BP patients there is evidence that both terminal complement activation (via complement component C5) and the lipid mediator leukotriene B4 (LTB4) have a central role in driving the disease. Ex vivo data in BP patients, published in the August 2019 edition of JCI Insight, showed a pronounced accumulation of LTB4 and C5 and its activation products in the inflamed skin of BP patients. This underlies the rationale for treatment with nomacopan which is a unique bifunctional inhibitor of both C5 and LTB4 and a range of downstream cytokines. In addition to BP, the Company believes this unique mode of action underpins the activity of nomacopan across the Company’s other target conditions – TMA-HSCT, COVID pneumonia and ophthalmology as well as other emerging clinical indications.About Akari Therapeutics Akari is a biopharmaceutical company focused on developing inhibitors of acute and chronic inflammation, specifically for the treatment of rare and orphan diseases, in particular those where the complement (C5) or leukotriene (LTB4) systems, or both complement and leukotrienes together, play a primary role in disease progression. Akari's lead drug candidate, nomacopan (formerly known as Coversin), is a C5 complement inhibitor that also independently and specifically inhibits leukotriene B4 (LTB4) activity.Cautionary Note Regarding Forward-Looking Statements Certain statements in this press release constitute “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. You should not place undue reliance upon the Company’s forward looking statements. Except as required by law, the Company undertakes no obligation to revise or update any forward-looking statements in order to reflect any event or circumstance that may arise after the date of this press release. These forward-looking statements reflect our current views about our plans, intentions, expectations, strategies and prospects, which are based on the information currently available to us and on assumptions we have made. Although we believe that our plans, intentions, expectations, strategies and prospects as reflected in or suggested by those forward-looking statements are reasonable, we can give no assurance that the plans, intentions, expectations or strategies will be attained or achieved. Furthermore, actual results may differ materially from those described in the forward-looking statements and will be affected by a variety of risks and factors that are beyond our control. Such risks and uncertainties for our company include, but are not limited to: needs for additional capital to fund our operations, our ability to continue as a going concern; uncertainties of cash flows and inability to meet working capital needs; an inability or delay in obtaining required regulatory approvals for nomacopan and any other product candidates, which may result in unexpected cost expenditures; our ability to obtain orphan drug designation in additional indications; risks inherent in drug development in general; uncertainties in obtaining successful clinical results for nomacopan and any other product candidates and unexpected costs that may result therefrom; difficulties enrolling patients in our clinical trials; our ability to enter into collaborative, licensing, and other commercial relationships and on terms commercially reasonable to us; failure to realize any value of nomacopan and any other product candidates developed and being developed in light of inherent risks and difficulties involved in successfully bringing product candidates to market; inability to develop new product candidates and support existing product candidates; the approval by the FDA and EMA and any other similar foreign regulatory authorities of other competing or superior products brought to market; risks resulting from unforeseen side effects; risk that the market for nomacopan may not be as large as expected; risks associated with the impact of the outbreak of coronavirus; risks associated with the SEC investigation; inability to obtain, maintain and enforce patents and other intellectual property rights or the unexpected costs associated with such enforcement or litigation; inability to obtain and maintain commercial manufacturing arrangements with third party manufacturers or establish commercial scale manufacturing capabilities; the inability to timely source adequate supply of our active pharmaceutical ingredients from third party manufacturers on whom the company depends; unexpected cost increases and pricing pressures and risks and other risk factors detailed in our public filings with the U.S. Securities and Exchange Commission, including our most recently filed Annual Report on Form 20-F filed with the SEC. Except as otherwise noted, these forward-looking statements speak only as of the date of this press release and we undertake no obligation to update or revise any of these statements to reflect events or circumstances occurring after this press release. We caution investors not to place considerable reliance on the forward-looking statements contained in this press release.Investor Contact:Peter Vozzo Westwicke +1 (443) 213-0505 peter.vozzo@westwicke.comMedia Contact:Sukaina Virji / Lizzie Seeley Consilium Strategic Communications +44 (0)20 3709 5700
GlobeNewswire · 10/27 14:00
Akari Therapeutics To Present Phase II Data From Bullous Pemphigoid Trial At European Academy Of Dermatology And Venereology (EADV) Virtual Congress October 29
Safety and efficacy data from Phase II clinical trial of nomacopan in adults with mild to moderate BP The Phase II data was the basis for the agreement of the FDA and the EMA that Akari may proceed to a Phase III
Benzinga · 10/27 13:03
Akari Therapeutics furthers clinal trials for Covid-19 pneumonia
Akari Therapeutics ([[AKTX]] -1.6%) announces further progress in its COVID-19 pneumonia program with nomacopan in the U.S. and Brazil.Nomacopan’s dual complement and leukotriene inhibition has applicability in a range of other severe lung inflammatory
Seekingalpha · 10/06 15:30
Akari Therapeutics Announces Further Clinical Trial Progress Using Nomacopan To Treat COVID-19 Pneumonia
Akari Therapeutics Announces Further Clinical Trial Progress Using Nomacopan to Treat COVID-19 Pneumonia FDA clearance received to proceed with investigator-led multi-center double blind
Benzinga · 10/06 12:35
Akari's nomacopan to enter late-stage skin blistering disorder study during next year
Akari Therapeutics ([[AKTX]] -4.6%) completes a scientific advice meeting with the European Medicines Agency ((EMA)) prior to initiation of a Phase 3 study of nomacopan for the treatment of bullous
Seekingalpha · 10/01 15:21
Akari Therapeutics Reports Successful Scientific Advice Meeting with EMA For Nomacopan For Treatment Of Bullous Pemphigoid
Akari Therapeutics, Plc (NASDAQ:AKTX), a biopharmaceutical company focused on innovative therapeutics to treat orphan autoimmune and inflammatory diseases where the complement and/or leukotriene systems are implicated,
Benzinga · 10/01 13:38
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Analyst Price Target
The average AKTX stock price target is 5.00 with a high estimate of 5.00 and a low estimate of 5.00.
Institutional Holdings
Institutions: 28
Institutional Holdings: 2.41M
% Owned: 6.26%
Shares Outstanding: 38.47M
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Biotechnology & Medical Research
Pharmaceuticals & Medical Research
Key Executives
Ray Prudo
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David Solomon
Chief Financial Officer
Torsten Hombeck
Chief Operating Officer/Director
Clive Richardson
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Nigel Hernandez
David Byrne
Peter Feldschreiber
Michael Grissinger
Robert Ward
Donald Williams
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James Hill
Non-Executive Director
Stuart Ungar
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About AKTX
Akari Therapeutics, Plc is a clinical-stage biopharmaceutical company. The Company is focused on the development and commercialization of treatments for a range of rare and orphan autoimmune and inflammatory diseases caused by dysregulation of complement component 5 (C5), including paroxysmal nocturnal hemoglobinuria, Guillain Barre syndrome and atypical Hemolytic Uremic Syndrome. The Company’s lead product candidate, nomacopan inhibits both terminal complement activation and leukotriene B4, or LTB4. It inhibits terminal complement activation by tightly binding to C5 and preventing its cleavage and activation by complement.
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