Metagenomi Therapeutics, Inc. is an in vivo genome editing company capitalizing on its proprietary technologies to create curative genetic medicines for patients. It discovers and develops a suite of novel editing tools potentially capable of correcting any type of genetic mutation found anywhere in the human genome. It focuses on value programs in disease indications with well-understood biology and clearly defined clinical development and regulatory pathways. Its lead candidate, MGX-001, is a wholly-owned development program in hemophilia A, has demonstrated a preclinical profile potentially competitive with treatment options, including targeted genome editing and durable gene expression in a one-time treatment. MGX-001 is designed to provide curative, life-long protection from bleeding events and joint damage in adults and children with hemophilia A. MGX-001 is designed to insert a Factor VIII (FVIII) DNA cassette into a safe harbor location within an intron of the albumin gene.