Muna Therapeutics reports positive Phase 1 results for Alzheimer's drug MNA-001

• Muna Therapeutics reported positive Phase 1 results for oral TREM2 modulator MNA-001, supporting development in early Alzheimer's disease.
• No deaths, serious adverse events or adverse-event-related discontinuations occurred; most adverse events were mild.
• Central nervous system exposure reached a cerebrospinal fluid-to-plasma ratio of approximately 1.7; target engagement was dose-dependent.
• Repeated dosing shifted elderly volunteers' age-related brain inflammation markers toward levels seen in younger healthy participants.
• Phase 2 is expected to start in Q2 2027, testing two doses against placebo over 48 weeks, with plasma pTau217 change primary.

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