Orexo reports oral semaglutide AmorphOX tablet shows bioavailability comparable to reference in first preclinical in vivo study

PUBT · 2d ago
Orexo reports oral semaglutide AmorphOX tablet shows bioavailability comparable to reference in first preclinical in vivo study
  • Orexo disclosed initial preclinical in vivo pharmacokinetic results for an oral semaglutide tablet using its AmorphOX technology.
  • Results have already been presented, showing the lead formulation matched the reference tablet’s bioavailability before any optimization.
  • Work now shifts to formulation optimization with an industry partner, targeting bioavailability that could outperform marketed oral alternatives.
  • The program broadens AmorphOX beyond intranasal use, supporting a strategy to enable needle-free delivery for peptides.


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