Vaccinex says neoadjuvant melanoma pilot study links pepinemab regimens to immune remodeling, longer recurrence-free survival

PUBT · 2d ago
Vaccinex says neoadjuvant melanoma pilot study links pepinemab regimens to immune remodeling, longer recurrence-free survival
  • Vaccinex announced a Nature Communications publication of results from an Emory-sponsored pilot neoadjuvant melanoma study of pepinemab.
  • Findings were already presented via publication, not flagged for a future conference release.
  • Pepinemab combinations reshaped the tumor immune environment in ways consistent with stronger anti-tumor immune activity.
  • More mature immune structures in tumors correlated with longer recurrence-free survival, though the small study was not designed to prove benefit.
  • Data support the strategy of pairing SEMA4D blockade with checkpoint inhibitors, with larger randomized trials needed for confirmation.


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