Alterity says ATH434 50 mg slows functional decline about 52% vs placebo in Phase 2 multiple system atrophy analysis

• Alterity Therapeutics presented new Phase 2 analyses of ATH434 in multiple system atrophy at the 2026 MDS Congress.
• Adjusted results showed the 50 mg dose slowed functional decline versus placebo over one year, strengthening the disease-modifying signal.
• Baseline CSF neurofilament light chain emerged as a predictor of progression, supporting its use to sharpen outcomes in a Phase 3 trial.
• Imaging analyses were broadly consistent with ATH434’s iron-chaperone approach, despite the study missing its primary imaging endpoint.

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