PepGen advances PGN-EDODM1 into 12.5 mg/kg cohort in Phase 2 FREEDOM2-DM1 trial

• PepGen will move PGN-EDODM1 into the highest-dose cohort in its Phase 2 FREEDOM2-DM1 study following a DSMB safety review.
• The DSMB also supported raising dosing in the open-label extension, reinforcing a safety profile that has remained broadly acceptable with repeat treatment.
• No serious adverse events, dose-limiting toxicities, cumulative toxicity signals, or treatment discontinuations have been reported so far in FREEDOM2 or the extension.
• Results from the fully enrolled 10 mg/kg cohort are scheduled for November; 12.5 mg/kg cohort results are expected in 1H 2027.
• An end-of-Phase 2 regulatory meeting is planned in 1H 2027 to discuss a registrational program; an extension update is expected by early January.

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