GH Research publishes corporate presentation on ultra-rapid, durable remission data for TRD treatment GH001

PUBT · 2d ago
GH Research publishes corporate presentation on ultra-rapid, durable remission data for TRD treatment GH001
  • GH Research highlighted Phase 2b data for GH001, an inhaled mebufotenin candidate for treatment-resistant depression.
  • Primary endpoint showed a least-squares mean MADRS change difference of -15.5 versus placebo on Day 8 (P<0.0001); Cohen’s d -2.
  • Remission (MADRS ≤10) reached 57.5% on Day 8; open-label extension completers showed 73% remission at 6 months.
  • Presentation emphasized an ~11-minute median psychoactive phase, positioning GH001 for a Spravato-compatible outpatient clinic workflow.
  • Cash, cash equivalents, and marketable securities totaled $362.7 million as of June 30, 2026; Phase 3 initiation targeted in 2026.


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