Aptevo files patent for Nectin-4 x PD-L1 dual-targeting backbone for solid tumor therapies

• Aptevo Therapeutics filed a patent application for a proprietary Nectin-4 x PD-L1 dual-targeting backbone aimed at solid tumors.
• Platform design supports multiple development paths from one targeting architecture, including radiopharmaceutical candidates or T-cell engager constructs.
• Strategy targets tumor localization via Nectin-4 while engaging PD-L1 to counter immune suppression, seeking better selectivity than single-target approaches.
• Backbone extends the company’s ADAPTIR and ADAPTIR-FLEX platforms, positioning the pipeline for additional payloads or immune-modulating functions.
• Filing strengthens intellectual property coverage, supporting partnering discussions and a broader solid-tumor pipeline build-out.

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