Merck wins EU approval for Erbitux combo as first-line treatment for BRAF V600E metastatic colorectal cancer

PUBT · 2d ago
Merck wins EU approval for Erbitux combo as first-line treatment for BRAF V600E metastatic colorectal cancer
  • Merck KGaA won European Commission clearance to expand Erbitux use in BRAF V600E-mutant metastatic colorectal cancer, including first-line therapy.
  • Label now covers Erbitux with encorafenib plus FOLFOX in previously untreated patients, positioning a targeted regimen at treatment start.
  • BREAKWATER Phase 3 results showed median overall survival of 30.3 months vs 15.1 months; hazard ratio 0.49.
  • Median progression-free survival reached 12.8 months vs 7.1 months; hazard ratio 0.53.
  • Erbitux with encorafenib also gained EU use in previously treated patients, supported by BEACON overall survival of 9.3 months vs 5.9 months.


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