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Alnylam Pharmaceuticals (ALNY): Is the Stock’s Recent Surge Justified by Its Valuation?

Simply Wall St · 2d ago

Alnylam Pharmaceuticals (ALNY) has quietly extended its strong run, with the stock up about 12% over the past month and nearly doubling over the past year, inviting a closer look at what investors are pricing in.

See our latest analysis for Alnylam Pharmaceuticals.

That surge in the share price to about $473, alongside a roughly 12% 1 month share price return and a standout year to date share price return above 100%, points to investors rapidly re rating Alnylam as growth prospects and perceived pipeline risk both shift in its favor.

If Alnylam’s run has you rethinking your healthcare exposure, this could be a good moment to scan other innovative names with healthcare stocks and see what else fits your strategy.

With shares hovering just below Wall Street’s target yet still trading at a notable intrinsic discount, the key question now is simple: is Alnylam still mispriced, or are markets already baking in years of growth?

Most Popular Narrative: 3.2% Undervalued

With Alnylam’s shares closing at $473.29 against a narrative fair value near $489, the story leans modestly optimistic, hinging on powerful growth assumptions ahead.

The rapid and robust uptake of AMVUTTRA for ATTR-CM in its first full quarter post-approval, combined with near-universal first-line payer access and minimal patient out-of-pocket costs, indicates a much larger addressable market for Alnylam's RNAi therapies as diagnostics and disease awareness improve, supporting sustained double-digit revenue growth.

Read the complete narrative.

Curious how this momentum translates into that higher fair value? The narrative leans on aggressive revenue expansion, rising margins, and a rich future earnings multiple. Want the full blueprint?

Result: Fair Value of $489.09 (UNDERVALUED)

Have a read of the narrative in full and understand what's behind the forecasts.

However, sustained pricing pressure on Amvuttra and ongoing heavy R&D spending could easily blunt that upbeat growth and margin story.

Find out about the key risks to this Alnylam Pharmaceuticals narrative.

Another View on Valuation

While the narrative fair value points to only a modest 3.2% upside, our DCF model is more generous, suggesting Alnylam is about 21% undervalued at $473 versus a fair value near $601. Is the cash flow math seeing something sentiment has not fully priced yet?

Look into how the SWS DCF model arrives at its fair value.

ALNY Discounted Cash Flow as at Dec 2025
ALNY Discounted Cash Flow as at Dec 2025

Build Your Own Alnylam Pharmaceuticals Narrative

If you see the story differently or want to dig into the numbers yourself, you can build a custom view in minutes with Do it your way.

A great starting point for your Alnylam Pharmaceuticals research is our analysis highlighting 3 key rewards and 2 important warning signs that could impact your investment decision.

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This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.