Across the recent three months, 24 analysts have shared their insights on Alnylam Pharmaceuticals (NASDAQ:ALNY), expressing a variety of opinions spanning from bullish to bearish.
Summarizing their recent assessments, the table below illustrates the evolving sentiments in the past 30 days and compares them to the preceding months.
| Bullish | Somewhat Bullish | Indifferent | Somewhat Bearish | Bearish | |
|---|---|---|---|---|---|
| Total Ratings | 12 | 9 | 3 | 0 | 0 |
| Last 30D | 2 | 0 | 0 | 0 | 0 |
| 1M Ago | 1 | 2 | 0 | 0 | 0 |
| 2M Ago | 8 | 5 | 2 | 0 | 0 |
| 3M Ago | 1 | 2 | 1 | 0 | 0 |
In the assessment of 12-month price targets, analysts unveil insights for Alnylam Pharmaceuticals, presenting an average target of $433.42, a high estimate of $583.00, and a low estimate of $333.00. This current average has increased by 18.7% from the previous average price target of $365.14.

The standing of Alnylam Pharmaceuticals among financial experts is revealed through an in-depth exploration of recent analyst actions. The summary below outlines key analysts, their recent evaluations, and adjustments to ratings and price targets.
| Analyst | Analyst Firm | Action Taken | Rating | Current Price Target | Prior Price Target |
|---|---|---|---|---|---|
| Patrick R. Trucchio | HC Wainwright & Co. | Maintains | Buy | $570.00 | $570.00 |
| David Lebovitz | Citigroup | Raises | Buy | $583.00 | $527.00 |
| Patrick Trucchio | HC Wainwright & Co. | Raises | Buy | $570.00 | $500.00 |
| Jessica Fye | JP Morgan | Raises | Overweight | $475.00 | $348.00 |
| Leland Gershell | Oppenheimer | Announces | Outperform | $490.00 | - |
| Greg Harrison | Scotiabank | Raises | Sector Outperform | $450.00 | $342.00 |
| Eliana Merle | UBS | Raises | Buy | $550.00 | $403.00 |
| Whitney Ijem | Canaccord Genuity | Raises | Buy | $415.00 | $390.00 |
| Tiago Fauth | Wells Fargo | Raises | Equal-Weight | $395.00 | $333.00 |
| Martin Auster | Raymond James | Raises | Outperform | $424.00 | $370.00 |
| Gena Wang | Barclays | Raises | Overweight | $460.00 | $329.00 |
| Edward Tenthoff | Piper Sandler | Raises | Overweight | $449.00 | $304.00 |
| Keay Nakae | Chardan Capital | Raises | Buy | $400.00 | $325.00 |
| Michael Ulz | Morgan Stanley | Raises | Equal-Weight | $405.00 | $312.00 |
| Joseph Stringer | Needham | Raises | Buy | $478.00 | $377.00 |
| Danielle Brill | Truist Securities | Announces | Buy | $385.00 | - |
| Jessica Fye | JP Morgan | Raises | Overweight | $348.00 | $338.00 |
| David Lebovitz | Citigroup | Raises | Buy | $404.00 | $364.00 |
| Tazeen Ahmad | B of A Securities | Raises | Buy | $359.00 | $336.00 |
| Maury Raycroft | Jefferies | Raises | Buy | $384.00 | $328.00 |
| Tiago Fauth | Wells Fargo | Raises | Equal-Weight | $333.00 | $287.00 |
| Joseph Stringer | Needham | Raises | Buy | $377.00 | $320.00 |
| Kostas Biliouris | BMO Capital | Raises | Outperform | $360.00 | $300.00 |
| Jessica Fye | JP Morgan | Raises | Overweight | $338.00 | $330.00 |
Understanding these analyst evaluations alongside key financial indicators can offer valuable insights into Alnylam Pharmaceuticals's market standing. Stay informed and make well-considered decisions with our Ratings Table.
Stay up to date on Alnylam Pharmaceuticals analyst ratings.
Alnylam Pharmaceuticals is a leader in the study of RNA interference (RNAi) therapeutics. RNAi is a naturally occurring biological pathway within cells for sequence-specific silencing and regulation of gene expression. Alnylam has five drugs on the market: Onpattro and Amvuttra for hATTR amyloidosis, Givlaari for acute hepatic porphyria, Oxlumo for primary hyperoxaluria type 1, and Leqvio for hypercholesterolemia. It also has several clinical programs across various therapeutic areas: genetic medicines; cardio-metabolic diseases; hepatic infectious diseases, and CNS/ocular diseases. Upfront fees from research partnerships have boosted Alnylam's cash levels, and the company stands to see additional milestones and royalties from drugs commercialized under collaboration partnerships.
Market Capitalization Analysis: With a profound presence, the company's market capitalization is above industry averages. This reflects substantial size and strong market recognition.
Revenue Growth: Over the 3M period, Alnylam Pharmaceuticals showcased positive performance, achieving a revenue growth rate of 17.26% as of 30 June, 2025. This reflects a substantial increase in the company's top-line earnings. When compared to others in the Health Care sector, the company faces challenges, achieving a growth rate lower than the average among peers.
Net Margin: Alnylam Pharmaceuticals's net margin excels beyond industry benchmarks, reaching -8.57%. This signifies efficient cost management and strong financial health.
Return on Equity (ROE): Alnylam Pharmaceuticals's ROE lags behind industry averages, suggesting challenges in maximizing returns on equity capital. With an ROE of -36.21%, the company may face hurdles in achieving optimal financial performance.
Return on Assets (ROA): Alnylam Pharmaceuticals's ROA falls below industry averages, indicating challenges in efficiently utilizing assets. With an ROA of -1.51%, the company may face hurdles in generating optimal returns from its assets.
Debt Management: With a high debt-to-equity ratio of 5.18, Alnylam Pharmaceuticals faces challenges in effectively managing its debt levels, indicating potential financial strain.
Analysts are specialists within banking and financial systems that typically report for specific stocks or within defined sectors. These people research company financial statements, sit in conference calls and meetings, and speak with relevant insiders to determine what are known as analyst ratings for stocks. Typically, analysts will rate each stock once a quarter.
In addition to their assessments, some analysts extend their insights by offering predictions for key metrics such as earnings, revenue, and growth estimates. This supplementary information provides further guidance for traders. It is crucial to recognize that, despite their specialization, analysts are human and can only provide forecasts based on their beliefs.
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This article was generated by Benzinga's automated content engine and reviewed by an editor.