Metastatic castration-sensitive prostate cancer (mCSPC), also known as metastatic hormone-sensitive prostate cancer (mHSPC), refers to prostate cancer that has spread beyond the prostate but still responds to therapies that lower testosterone (castration) with an aging population, the incidence of prostate cancer is rising, leading to an increased demand for advanced therapies to treat metastatic forms of the disease.
LAS VEGAS, Oct. 15, 2024 /PRNewswire/ -- DelveInsight's 'Metastatic Castration-Sensitive Prostate Cancer Pipeline Insight 2024' report provides comprehensive global coverage of pipeline mCSPC therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the mCSPC pipeline domain.
Key Takeaways from the Metastatic Castration-Sensitive Prostate Cancer Pipeline Report
Request a sample and discover the recent advances in mCSPC treatment drugs @ Metastatic Castration-Sensitive Prostate Cancer Pipeline Report
The mCSPC pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage mCSPC drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the mCSPC clinical trial landscape.
Metastatic Castration-Sensitive Prostate Cancer Overview
Metastatic castration-sensitive prostate cancer (mCSPC) is an advanced form of prostate cancer in which the cancer cells have spread beyond the prostate to other parts of the body, such as bones or lymph nodes, but remain responsive to hormone therapy. This means that reducing testosterone levels can still effectively slow the growth of cancer cells. mCSPC often arises when prostate cancer is initially diagnosed or when early-stage prostate cancer recurs after treatment. It is distinct from castration-resistant prostate cancer (CRPC), where the cancer continues to progress despite low testosterone levels.
The causes of mCSPC primarily involve the spread of prostate cancer cells beyond the local prostate region, a process called metastasis. Although the exact mechanisms are complex, certain risk factors increase the likelihood of developing prostate cancer and its progression to metastatic disease. These risk factors include advanced age, a family history of prostate cancer, genetic mutations such as BRCA1/BRCA2, and race. Symptoms of mCSPC can include bone pain, urinary issues, fatigue, weight loss, and general malaise, especially if the cancer has spread to bones or lymph nodes. However, in many cases, early stages of metastasis may be asymptomatic, making regular screening essential for those at risk.
Diagnosis of mCSPC typically involves a combination of blood tests, such as measuring prostate-specific antigen (PSA) levels, imaging studies, and biopsy to confirm the presence of cancer cells. Treatment for mCSPC revolves around androgen deprivation therapy to lower testosterone levels, often combined with other agents like chemotherapy (e.g., docetaxel) or second-generation androgen receptor inhibitors (e.g., abiraterone or enzalutamide). In recent years, clinical trials have shown the benefit of combining ADT with novel therapies to improve survival rates and manage symptoms, with personalized treatment approaches based on genetic testing becoming more common.
Find out more about mCSPC treatment drugs @ Drugs for Metastatic Castration-Sensitive Prostate Cancer Treatment
A snapshot of the mCSPC Pipeline Drugs mentioned in the report:
Drugs |
Company |
Phase |
MoA |
RoA |
TAVT-45 (abiraterone acetate) |
Tavanta Therapeutics |
Phase III |
CYP17A1 protein inhibitors |
Oral |
Saruparib (AZD5305) |
AstraZeneca |
Phase III |
Poly(ADP-ribose) polymerase-1 inhibitors |
Oral |
Capivasertib |
AstraZeneca |
Phase III |
Proto-oncogene protein c-akt inhibitors |
Oral |
REGN2810 |
Regeneron Pharmaceuticals |
Phase II |
Antibody-dependent cell cytotoxicity; Programmed cell death 1 receptor antagonists; T lymphocyte stimulants |
Intravenous |
Abiraterone decanote + dexamethasone or prednisone (PRL-02/ASP5541) |
Astellas Pharma/Propella Therapeutics |
Phase I/II |
CYP17 lyase inhibitor |
Intramuscular |
[Ac-225]-PSMA-62 |
POINT Biopharma |
Phase I |
Ionizing radiation emitters |
Intravenous |
Xaluritamig |
Amgen |
Phase I |
Antibody-dependent cell cytotoxicity; Immunostimulants; T lymphocyte stimulants |
Intravenous |
Learn more about the emerging mCSPC pipeline therapies @ Metastatic Castration-Sensitive Prostate Cancer Clinical Trials
Metastatic Castration-Sensitive Prostate Cancer Therapeutics Assessment
The mCSPC pipeline report proffers an integral view of the mCSPC emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration.
Scope of the Metastatic Castration-Sensitive Prostate Cancer Pipeline Report
Dive deep into rich insights for new drugs for mCSPC treatment, visit @ Metastatic Castration-Sensitive Prostate Cancer Drugs
Table of Contents
1. |
Metastatic Castration-Sensitive Prostate Cancer Pipeline Report Introduction |
2. |
Metastatic Castration-Sensitive Prostate Cancer Pipeline Report Executive Summary |
3. |
Metastatic Castration-Sensitive Prostate Cancer Pipeline: Overview |
4. |
Analytical Perspective In-depth Commercial Assessment |
5. |
Metastatic Castration-Sensitive Prostate Cancer Clinical Trial Therapeutics |
6. |
Metastatic Castration-Sensitive Prostate Cancer Pipeline: Late-Stage Products (Pre-registration) |
7. |
Metastatic Castration-Sensitive Prostate Cancer Pipeline: Late-Stage Products (Phase III) |
8. |
Metastatic Castration-Sensitive Prostate Cancer Pipeline: Mid-Stage Products (Phase II) |
9. |
Metastatic Castration-Sensitive Prostate Cancer Pipeline: Early-Stage Products (Phase I) |
10. |
Metastatic Castration-Sensitive Prostate Cancer Pipeline Therapeutics Assessment |
11. |
Inactive Products in the Metastatic Castration-Sensitive Prostate Cancer Pipeline |
12. |
Company-University Collaborations (Licensing/Partnering) Analysis |
13. |
Key Companies |
14. |
Key Products in the Metastatic Castration-Sensitive Prostate Cancer Pipeline |
15. |
Unmet Needs |
16. |
Market Drivers and Barriers |
17. |
Future Perspectives and Conclusion |
18. |
Analyst Views |
19. |
Appendix |
For further information on the mCSPC Cancer pipeline therapeutics, reach out @ Metastatic Castration-Sensitive Prostate Cancer Treatment Drugs
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