MARKET

AGEN

AGEN

Agenus
NASDAQ

Real-time Quotes | Nasdaq Last Sale

3.330
-0.060
-1.77%
After Hours: 3.330 0 0.00% 19:29 12/04 EST
OPEN
3.420
PREV CLOSE
3.390
HIGH
3.420
LOW
3.280
VOLUME
2.55M
TURNOVER
--
52 WEEK HIGH
5.63
52 WEEK LOW
1.820
MARKET CAP
633.20M
P/E (TTM)
-3.0607
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Agenus extends timeline for U.S. balstilimab application after two late responders identified
Agenus (AGEN) announces that it now expects to complete its rolling U.S. marketing application seeking approval of PD-1 inhibitor balstilimab for the treatment of recurrent/metastatic cervical cancer in H1 2021
Seekingalpha · 2d ago
Completion of Balstilimab BLA Filing Extended To 1H2021
Agenus to fulfill FDA feedback for six-month follow-up on late respondersLEXINGTON, Mass., Dec. 03, 2020 (GLOBE NEWSWIRE) -- Agenus Inc. (NASDAQ: AGEN), an immuno-oncology company with a broad pipeline which includes checkpoint antibodies, cell therapies, adjuvants, and vaccines designed to activate immune response to cancers and infections, today announced updated timing of the balstilimab BLA filing to meet the FDA feedback to follow all patients for a median of 12 months and responders for a minimum of 6 months. Due to two newly-identified late responses in the trial, the completion of the BLA filing is planned for the first half of 2021. In parallel, Agenus is working with the FDA to clarify diagnostic requirements for PD-L1 testing. The additional follow-up is required to present data on two patients who experienced durable disease stabilization and converted to confirmed responses on long-term balstilimab therapy.About Agenus Agenus is a clinical-stage immuno-oncology company focused on the discovery and development of therapies that engage the body's immune system to fight cancer. The Company's vision is to expand the patient populations benefiting from cancer immunotherapy by pursuing combination approaches that leverage a broad repertoire of antibody therapeutics, adoptive cell therapies (through its AgenTus Therapeutics subsidiary), and proprietary cancer vaccine platforms. The Company is equipped with a suite of antibody discovery platforms and a state-of-the-art GMP manufacturing facility with the capacity to support clinical programs. Agenus is headquartered in Lexington, MA. For more information, please visit www.agenusbio.com and our Twitter handle @agenus_bio. Information that may be important to investors will be routinely posted on our website and Twitter.Forward-Looking Statements This press release contains forward-looking statements that are made pursuant to the safe harbor provisions of the federal securities laws, including statements regarding regulatory timelines for the BLA filings of balstilimab alone and in combination with zalifrelimab. These forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially. These risks and uncertainties include, among others, the factors described under the Risk Factors section of our most recent Quarterly Report on Form 10-Q or Annual Report on Form 10-K filed with the Securities and Exchange Commission. Agenus cautions investors not to place considerable reliance on the forward-looking statements contained in this release. These statements speak only as of the date of this press release, and Agenus undertakes no obligation to update or revise the statements, other than to the extent required by law. All forward-looking statements are expressly qualified in their entirety by this cautionary statement.Contact: Agenus Inc.  Caroline Bafundo 212-994-8209 Caroline.Bafundo@agenusbio.com
GlobeNewswire · 2d ago
Agenus Launches Phase 2 Trial Expansion in Colon Cancer for AGEN1181 in Combination with Balstilimab
New objective response in colon cancer triggers trial expansionLEXINGTON, Mass., Dec. 01, 2020 (GLOBE NEWSWIRE) -- Agenus Inc. (NASDAQ: AGEN), an immuno-oncology company with a broad pipeline which includes checkpoint antibodies, cell therapies, adjuvants, and vaccines designed to activate immune response to cancers and infections, today announced the expansion of a Phase 2 trial into colon cancer based on a new objective clinical response in a colorectal cancer patient in addition to a significant tumor reduction of 27% and biomarker reduction observed in a patient with MSS colon cancer. With this recent response in colon cancer, AGEN1181 +/- balstilimab (anti-PD-1) has reported 4 clinical responses plus a significant tumor reduction of more than 27% in a fifth patient. In addition, 19 patients have achieved disease stabilization out of 41 patients treated in what was designed as a dose escalation study.Recently, Agenus also presented on the first-ever report of intratumoral Treg depletion with a CTLA-4 antibody in clinical trials. The summary of responses achieved with AGEN1181 alone or in combination with balstilimab are as follows: * CR in PD-L1(-) MSS endometrial cancer patient (1181 monotherapy) * CR in PD-L1(-) MSS endometrial cancer patient (1181 + bali) * PR in a colorectal cancer patient (1181 + bali) * PR in PD-L1(-) refractory ovarian cancer patient (rescued with 1181 + bali) – previous stable disease for 66 weeks with 1181 monotherapy * Major tumor reduction (27%) in MSS colorectal cancer with remarkable CEA biomarker reduction from 298 to 2 (1181 + bali) In the phase 1 trial of AGEN1181, clinical benefit and responses have been seen in patients with polymorphism in FcyRIIIA alleles who are not responsive to first-generation CTLA-4 antibodies.The Phase 2, open-label, multicenter study will focus primarily on colorectal cancer and select solid tumors, such as lung cancer and melanoma.“These early data are very exciting, particularly in aggressive tumors that have traditionally been unresponsive to immune therapies, like colorectal cancer,” said Dr. Joseph Grossman, expert in gastrointestinal cancers and the Head of Exploratory Medicine at Agenus. “AGEN1181 has potential to not only broaden the population of responders to CPIs, but also to reach tumors traditionally considered “cold” or unresponsive to immune therapies. I am excited to see the potential broadened benefit of our next-generation anti-CTLA-4’s design, particularly its Fc-enhancement, and the validation of Agenus’ incredible R&D capabilities.”Dr. Joseph Grossman recently joined Agenus as head of exploratory medicine from Harvard Medical School, where he was an instructor in medicine, and Beth Israel Deaconess Medical Center, where he served as an attending physician in GI oncology. He completed his residency and fellowship in hematology oncology at Beth Israel Deaconess Medical Center. He holds a postbaccalaureate certificate in premedical sciences from Columbia University in the City of New York and an MD from Brown Medical School.About Agenus Agenus is a clinical-stage immuno-oncology company focused on the discovery and development of therapies that engage the body's immune system to fight cancer. The Company's vision is to expand the patient populations benefiting from cancer immunotherapy by pursuing combination approaches that leverage a broad repertoire of antibody therapeutics, adoptive cell therapies (through its AgenTus Therapeutics subsidiary), and proprietary cancer vaccine platforms. The Company is equipped with a suite of antibody discovery platforms and a state-of-the-art GMP manufacturing facility with the capacity to support clinical programs. Agenus is headquartered in Lexington, MA. For more information, please visit www.agenusbio.com and our Twitter handle @agenus_bio. Information that may be important to investors will be routinely posted on our website and Twitter.Forward-Looking Statements This press release contains forward-looking statements that are made pursuant to the safe harbor provisions of the federal securities laws, including statements regarding the therapeutic and curative potential of AGEN1181. These forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially. These risks and uncertainties include, among others, the factors described under the Risk Factors section of our most recent Quarterly Report on Form 10-Q or Annual Report on Form 10-K filed with the Securities and Exchange Commission. Agenus cautions investors not to place considerable reliance on the forward-looking statements contained in this release. These statements speak only as of the date of this press release, and Agenus undertakes no obligation to update or revise the statements, other than to the extent required by law. All forward-looking statements are expressly qualified in their entirety by this cautionary statement.Contact: Agenus Inc.  Caroline Bafundo 212-994-8209 Caroline.Bafundo@agenusbio.com
GlobeNewswire · 4d ago
Agenus to Participate in Evercore ISI 3rd Annual HealthCONx Conference
Agenus Inc. (NASDAQ: AGEN), an immuno-oncology company with an extensive pipeline of checkpoint antibodies, cell therapies, adjuvants, and vaccines designed to activate immune response to cancers and infections, today announced that Dr. Jennifer Buell, President and COO of Agenus, will participate in a fireside chat hosted by Umer Raffat at the Evercore ISI 3rd Annual HealthCONx Conference on Thursday, December 3, 2020 from 10:55 AM - 11:15 AM EST.
GlobeNewswire · 11/25 18:28
Agenus to Participate in Evercore ISI 3rd Annual HealthCONx Conference
LEXINGTON, Mass., Nov. 25, 2020 (GLOBE NEWSWIRE) -- Agenus Inc. (NASDAQ: AGEN), an immuno-oncology company with an extensive pipeline of checkpoint antibodies, cell therapies, adjuvants, and vaccines designed to activate immune response to cancers and infections, today announced that Dr. Jennifer Buell, President and COO of Agenus, will participate in a fireside chat hosted by Umer Raffat at the Evercore ISI 3rd Annual HealthCONx Conference on Thursday, December 3, 2020 from 10:55 AM – 11:15 AM EST. Dr. Buell will provide an update on clinical programs, including AGEN1181, and corporate progress.Registration for the webinar can be done in advance at https://wsw.com/webcast/evercore11/register.aspx?conf=evercore11&page=agen&url=https://wsw.com/webcast/evercore11/agen/2321775.A replay will be available after the call on the Events & Presentations page of the Agenus website at https://investor.agenusbio.com/events-and-presentations.   About Agenus Agenus is a clinical-stage immuno-oncology company focused on the discovery and development of therapies that engage the body's immune system to fight cancer. The Company's vision is to expand the patient populations benefiting from cancer immunotherapy by pursuing combination approaches that leverage a broad repertoire of antibody therapeutics, adoptive cell therapies (through its AgenTus Therapeutics subsidiary), and proprietary cancer vaccine platforms. The Company is equipped with a suite of antibody discovery platforms and a state-of-the-art GMP manufacturing facility with the capacity to support clinical programs. Agenus is headquartered in Lexington, MA. For more information, please visit www.agenusbio.com and our Twitter handle @agenus_bio. Information that may be important to investors will be routinely posted on our website and Twitter.Contact: Agenus Inc.  Caroline Bafundo        212-994-8209 Caroline.Bafundo@agenusbio.com
GlobeNewswire · 11/25 18:28
VBI Vaccines Announces Positive Interim Phase 2a Data From VBI-1901 In Recurrent GBM
VBI Vaccines Announces Positive Interim Phase 2a Data from VBI-1901 in Recurrent GBM - Interim data show promising disease control rates in patients vaccinated with VBI-1901 combined with the GM-CSF adjuvant (40%), and
Benzinga · 11/19 13:08
VBI Vaccines Announces Positive Interim Phase 2a Data from VBI-1901 in Recurrent GBM
--- 2 partial responses observed in VBI-1901 + GM-CSF study arm, with tumor reduction of more than 50%, and 7 stable disease observations across both vaccinated groups
BusinessWire · 11/19 10:00
Agenus to Participate in Fireside Chat at the Jefferies 2020 Virtual London Healthcare Conference
Agenus Inc. (NASDAQ: AGEN), an immuno-oncology company with an extensive pipeline of checkpoint antibodies, cell therapies, adjuvants, and vaccines designed to activate immune response to cancers and infections, today announced that Dr. Jennifer Buell, President and COO of Agenus, will participate in a fireside chat at the Jefferies 2020 Virtual London Healthcare Conference on Tuesday, November 17, 2020 from 4:25 PM - 4:55 PM GMT / 11:25 AM - 11:55 AM EST.
GlobeNewswire · 11/17 00:04
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Analyst Rating

Based on 3 analysts

Strong Buy

Disclaimer: The analysis information is for reference only and does not constitute an investment recommendation.

Analyst Price Target
The average AGEN stock price target is 8.00 with a high estimate of 8.00 and a low estimate of 8.00.
EPS
Institutional Holdings
Institutions: 194
Institutional Holdings: 103.60M
% Owned: 54.48%
Shares Outstanding: 190.15M
TypeInstitutionsShares
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51
15.99M
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1.28M
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5.39M
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Biotechnology & Medical Research
+2.89%
Pharmaceuticals & Medical Research
+1.72%
Key Executives
Chairman/Chief Executive Officer/Co-Founder/Director
Garo Armen
President/Chief Operating Officer
Jennifer Buell
Chief Accounting Officer/Vice President - Finance
Christine Klaskin
Chief Compliance Officer/Vice President/General Counsel/Secretary
Evan Kearns
Vice President
Don Vidic
Vice President
Donald Vidic
Lead Director/Independent Director
Timothy Wright
Director
Paul Clark
Director
Susan Hirsch
Independent Director
Brian Corvese
Independent Director
Allison Jeynes-Ellis
Independent Director
Wadih Jordan
Independent Director
Ulf Wiinberg
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About AGEN
Agenus Inc. (Agenus) is an immuno-oncology (I-O) company. The Company focuses on the discovery and development of therapies that engage the body's immune system to fight cancer. It is developing a I-O portfolio driven by platforms and programs, such as antibody discovery platforms, including Retrocyte Display, SECANT yeast display and phage display technologies designed to produce human antibodies; antibody candidate programs, including checkpoint modulator (CPM) programs; vaccine programs, including Prophage, AutoSynVax and PhosPhoSynVax, and saponin-based vaccine adjuvants, principally QS-21 Stimulon adjuvant (QS-21 Stimulon). The Company's discovery pipeline includes a range of checkpoint modulating (CPM) antibodies. The Company's vaccine platforms include its heat shock protein (HSP)-based Prophage vaccine candidates, and its synthetic vaccine candidates, ASV and PSV.
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