ADC Therapeutics’ Zynlonta-glofitamab combination shows 88.7% response rate in Phase 1b lymphoma trial

PUBT · 18h ago
ADC Therapeutics’ Zynlonta-glofitamab combination shows 88.7% response rate in Phase 1b lymphoma trial
  • ADC Therapeutics will present Zynlonta clinical results at the American Society of Hematology meeting, December 12-15, 2026, in New Orleans.
  • Phase 3 LOTIS-5 showed Zynlonta with rituximab delayed disease progression versus R-GemOx in relapsed or refractory DLBCL, without significantly improving overall survival.
  • Fatal adverse events were more frequent with Zynlonta under the protocol-defined reporting window, but less frequent under a shorter post-treatment window.
  • Updated Phase 1b LOTIS-7 results showed durable responses with Zynlonta combined with glofitamab, supporting further Phase 3 investigation.
  • A Phase 2 marginal zone lymphoma study showed durable complete responses with Zynlonta monotherapy, supporting potential expansion into additional treatment settings.


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