Kiora Pharmaceuticals Presents Plans for Global Phase 3 Trial of KIO-401 in Retinal Artery Occlusion

PUBT · 4d ago
Kiora Pharmaceuticals Presents Plans for Global Phase 3 Trial of KIO-401 in Retinal Artery Occlusion
  • Kiora Pharmaceuticals added KIO-401, a Phase 3-ready oral calpain inhibitor for central retinal artery occlusion, securing rights outside Asia from Senju Pharmaceutical.
  • A planned global Phase 3 trial will enroll approximately 144 patients across up to 50 sites.
  • Japan Phase 3 visual acuity results showed p=0.0949 overall versus p=0.0195 in patients with baseline vision worse than 20/400.
  • Planned NAION development includes a Phase 2b trial enrolling approximately 272 patients, with label expansion targeted for 2033.
  • KIO-301 remains in an actively enrolling Phase 2 trial for advanced retinitis pigmentosa.


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