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Teva Pharmaceuticals Announces Data Evaluating AJOVY Injection Use In Patients With Migraine Presented At 2022 American Headache Society Annual Meeting

Teva Pharmaceuticals, a U.S. affiliate of Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA), today announced results from a U.S. retrospective study examining real-world concomitant use of AJOVY

Benzinga · 06/09/2022 08:05

Teva Pharmaceuticals, a U.S. affiliate of Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA), today announced results from a U.S. retrospective study examining real-world concomitant use of AJOVY (fremanezumab-vfrm) injection and gepants in the prevention and acute treatment of migraine. The data showing a reduction in monthly migraine days with the treatment combination were presented as a late-breaking poster during the 2022 American Headache Society (AHS) Annual Meeting held June 9-12, 2022, in Denver, Colorado.

Data presentations at AHS included eight abstracts examining real-world use of AJOVY across different patient populations and clinical circumstances. In an additional poster presentation, results of a subgroup analysis from the Phase 3b FOCUS study examining the use of AJOVY in patients with difficult-to-treat migraine and comorbid obesity were reported. The real-world effectiveness of fremanezumab in patients with refractory migraine from a US tertiary headache center who switched from erenumab study was also highlighted.

“The breadth of real-world evidence presented at this year’s AHS meeting across different patient populations and practice settings underscores the value of AJOVY in helping to manage this disabling neurological disease,” said Denisa Hurtukova, MD, VP, Head of North America Medical Affairs. “As the migraine treatment landscape continues to advance, these data provide important insights about AJOVY in real-world settings and its use as a migraine preventive treatment across a spectrum of patients.”

Real-World Effectiveness and Tolerability of Fremanezumab for the Preventive Treatment of Migraine in Patients Using Concomitant Gepants for Acute Treatment in a US Neurology Practice

The US retrospective chart review study examined data from electronic medical records of 55 adult patients (age 18 and older) from the Dent Neurologic Institute, a multi-location practice in New York, who used AJOVY for preventive migraine treatment and concomitant gepants for acute migraine treatment between January 1, 2020 and May 1, 2021. Data were collected on patients with chronic and episodic migraine. Patients were on a gepant therapy for one or more months pre- and post-initiation of AJOVY as add-on therapy. Patients with three or more measurements of monthly migraine days (MMD) were included in the analysis: one at the pre-index date (gepant initiation), one at index (AJOVY initiation), and one at the post-index period (gepant + AJOVY).

At the time of AJOVY initiation, patients had an average (standard deviation) of 15.8 (7.4) MMD. The average time from the index date to the last visit was 9.4 (4.5) months. The average change in MMD from the index to the post-index date was -6.5 (1.0) days, representing a 41.1% reduction. Five patients (9.1%) had adverse events post-index; 3 injection site reactions, 1 uveitis and 1 upset stomach.

“Millions of people suffer from migraine and its debilitating effects, and finding the right treatment combination can be challenging. Different treatment approaches can be used synergistically, but given that these are relatively new treatments, real-world data on the concomitant use of AJOVY and gepants is limited,” said Jennifer McVige, M.D., MA, Attending Neurologist, DENT Neurologic Institute in Amherst, NY. “This study provides some of the first evidence that this treatment combination resulted in reductions in monthly migraine days. Continued investigation into this treatment approach is warranted.”