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BridgeBio Pharma To Present Phase 2b Data And Pivotal Phase 3 Study Design Of Encaleret In Autosomal Dominant Hypocalcemia Type 1 At The Endocrine Society 2022 Annual Conference

BridgeBio Pharma, Inc. (NASDAQ:BBIO) (“BridgeBio” or the “Company”), a commercial-stage biopharmaceutical company focused on genetic diseases and cancers, today announced that 24-week Phase 2b

Benzinga · 06/09/2022 07:37

BridgeBio Pharma, Inc. (NASDAQ:BBIO) (“BridgeBio” or the “Company”), a commercial-stage biopharmaceutical company focused on genetic diseases and cancers, today announced that 24-week Phase 2b data of encaleret in patients with autosomal dominant hypocalcemia type 1 (ADH1) will be featured in an oral presentation at the Endocrine Society (ENDO) 2022 Annual Conference, taking place in Atlanta, GA on June 11 – 14, 2022.

At ENDO 2022, BridgeBio will also participate in a rapid-fire poster presentation and share poster presentations about its achondroplasia program, including preclinical data on hypochondroplasia as well as an ePoster about its congenital adrenal hyperplasia (CAH) program. Full oral presentation and poster details for the ADH1, achondroplasia and CAH programs are listed below.

ADH1 oral presentation details:

Encaleret (CLTX-305) restored mineral homeostasis in a Phase 2 study in autosomal dominant hypocalcemia type 1 (ADH1)
Presenter: Rachel Gafni, M.D., senior research physician and head of the Mineral Homeostasis Studies Group of the National Institute of Dental and Craniofacial Research of the National Institutes of Health (NIH)
Oral session date & time: Monday, June 13th at 11:00 am – 12:30 pm ET
Oral presentation time: 11:15 – 11:30 am ET
Location: A411
Session number: OR21

Achondroplasia poster and rapid-fire poster presentation details:

Evaluation of body mass index and metabolic parameters in children with achondroplasia participating in the PROPEL study
Presenter: Daniela Rogoff, M.D., Ph.D., vice president of clinical development at QED Therapeutics, an affiliate company of BridgeBio
Poster presentation date & time: Saturday, June 11th at 1:00 – 3:00 pm ET
Location: Hall A1
Session number: PSAT105

Infigratinib in children with achondroplasia: Design of the PROPEL, PROPEL2 and PROPEL OLE studies
Presenter: Elena Muslimova, M.D., Ph.D., medical director at QED Therapeutics
Poster presentation date & time: Saturday, June 11th at 1:00 – 3:00 pm ET
Location: Hall A1
Session number: PSAT106

Qualitative research in children and parents of children with achondroplasia to cognitively debrief three patient-reported outcome measures and confirm the content validity of a clinical-assessed measure
Presenter: Elena Muslimova, M.D., Ph.D., medical director at QED Therapeutics
Poster presentation date & time: Saturday, June 11th at 1:00 – 3:00 pm ET
Location: Hall A1
Session number: PSAT102

Qualitative research in children with achondroplasia and parents of children with achondroplasia: Medical challenges and impacts
Presenter: Elena Muslimova, M.D., Ph.D., medical director at QED Therapeutics
Poster presentation date & time: Saturday, June 11th at 1:00 – 3:00 pm ET
Location: Hall A1
Session number: PSAT103

Medical history of children enrolled in PROPEL: A prospective clinical assessment study in children with achondroplasia
Presenter: Melita Irving, clinical geneticist at Guy's and St Thomas' NHS Foundation Trust, London
Poster presentation date, time & location: Monday, June 13th at 12:30 – 2:30 pm ET in Hall A1
Rapid-fire poster presentation date, time & location: Monday, June 13th at 12:58 – 1:03 pm ET in Pod 9
Session number: PMON326

Low-dose infigratinib, an oral selective fibroblast growth factor receptor tyrosine kinase inhibitor, demonstrates activity in a preclinical model of hypochondroplasia
Presenter: Carl Dambkowski, M.D., chief medical officer of QED Therapeutics
Poster presentation date & time: Monday, June 13th at 12:30 – 2:30 pm ET
Location: Hall A1
Session number: PMON30

CAH ePoster details:

Initial lessons from a pre-screening protocol to identify participants with classic CAH potentially eligible for gene therapy treatment with BBP-631, an adeno associated virus (AAV) serotype 5-based recombinant vector encoding the human CYP21A2 gene
Presenter: Kamal Bharucha, M.D., Ph.D., vice president of clinical development at BridgeBio Gene Therapy