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Aptinyx To Present Preclinical Data On NYX-783 In Models Of PTSD At 2022 Society Of Biological Psychiatry Annual Meeting

Aptinyx Inc. (NASDAQ:APTX), a clinical-stage biopharmaceutical company developing transformative therapies for the treatment of brain and nervous system disorders, today presented data from preclinical studies of NYX-783

Benzinga · 04/29/2022 07:38

Aptinyx Inc. (NASDAQ:APTX), a clinical-stage biopharmaceutical company developing transformative therapies for the treatment of brain and nervous system disorders, today presented data from preclinical studies of NYX-783 in models of post-traumatic stress disorder (PTSD) at the Society of Biological Psychiatry (SOBP) Annual Meeting, being held April 28 – April 30, 2022 in New Orleans, Louisiana. The company is participating in a symposium discussing the role of NMDA receptor function in relation to prefrontal cortex activity in PTSD.

“The data presented in today’s symposium highlight the potential of NMDA receptor modulation in key brain regions as a novel treatment approach for PTSD,” said Harald Murck, M.D., Ph.D., Vice President of Clinical and Medical Affairs at Aptinyx. “Activation of NMDA receptors in the prefrontal cortex is understood to contribute to addressing the underlying glutamatergic dysfunction associated with PTSD. The approach provides an opportunity for a new class of therapeutics. NYX-783, an NMDA receptor positive allosteric modulator, demonstrates an ability to build long-lasting fear-inhibitory memories in PTSD-relevant models, ultimately leading to a stabilization of fear extinction. We look forward to continuing the development of NYX-783 in our ongoing Phase 2b study of PTSD to help advance new therapies for the millions of people living with post-traumatic stress disorder.”

A full publication of the preclinical data from NYX-783 in PTSD was recently published in the journal, Molecular Psychiatry.

Symposium Title: “The Role of NMDA Receptor Function in Relation to Prefrontal Cortex Activity in Posttraumatic Stress Disorder” Harald Murck, M.D., Ph.D., (Chair), Chadi Abdallah, M.D., (Presenter), Adriana Feder, M.D., (Presenter), Eva Maria Fritz, Ph.D., (Presenter), Amanda Barth, Ph.D. (Presenter)

SYMPOSIUM DETAILS

Symposium Session: Friday, April 29, 2022: 1:30 PM - 3:30 PM ET (Grand Salon C)

Speakers and presentations:

  • Symposium Chair – Harald Murck, M.D., Ph.D. (Aptinyx)
  • “Reduced Prefrontal Synaptic Strength in Posttraumatic Stress Disorder (PTSD)” – Chadi Abdallah, M.D. (Baylor College of Medicine)
  • “Neural Circuitry Mechanisms of Response to Ketamine in PTSD: Preliminary Findings” – Adriana Feder, M.D. (Icahn School of Medicine at Mount Sinai)
  • “Neurobiological and Physiological Correlates of PTSD-Related Symptoms in Animal Models” Eva Maria Fritz, Ph.D., (University of Innsbruck)
  • “NYX-783, a Novel Positive Allosteric Modulator of the N-Methyl D-Aspartate Receptor, Increases NMDAR-Mediated Signaling in the Infralimbic Prefrontal Cortex to Facilitate Extinction Learning in PTSD-Relevant Rodent Models” – Amanda Barth, Ph.D. (Aptinyx)