AbbVie (NYSE:ABBV) today announced it will present results from several studies, including the DYSCOVER study evaluating the efficacy of DUODOPA® (levodopa/carbidopa intestinal gel) on the duration and severity of dyskinesia in patients with advanced Parkinson's disease (PD), at the 2020 International Congress of Parkinson's Disease and Movement Disorders® Virtual Congress, September 12-16. In total, 18 abstracts will be presented, including an overview of the pivotal Phase 3 study design for the investigational medicine ABBV-951 in patients with advanced PD, several studies evaluating the economic burden of PD, as well new and updated data evaluating AbbVie's neuroscience portfolio and pipeline.
The 12-week DYSCOVER study is the first randomized clinical trial comparing the efficacy of DUODOPA to optimized medical treatment (OMT) on dyskinesia in advanced PD patients using the Unified Dyskinesia Rating Scale (UDysRS), which measures all aspects of dyskinesia with a comprehensive score as the primary endpoint.
The study design for the multi-country, open-label, single arm, 52-week pivotal phase 3 study of ABBV-951 (foscarbidopa/foslevodopa), a subcutaneous delivery of levodopa/carbidopa being investigated for the treatment of advanced PD, will also be presented. The study is evaluating the local and systemic safety and tolerability of ABBV-951 delivered as a continuous, all-day subcutaneous infusion via an external pump for up to 52 weeks in people with advanced PD. The study is in process and estimated to conclude in late 2021.
"At AbbVie, we are resolute in our commitment to address the unmet needs of people living with neurologic diseases through new and innovative solutions," said Michael Gold, MD, Vice President, Neuroscience Development. "In the face of uncertainty and the unknown, we are determined to preserve personhood. We look forward to participating in the MDS 2020 Virtual Congress and sharing our latest research with scientists and healthcare professionals from around the globe."
Other data presentations include analyses from several DUODOPA-related studies, including the COSMOS Observational Study, a multi-country, cross-sectional, retrospective, post-marketing observational study that enrolled patients with advanced PD who were treated with DUODOPA for more than 12 months. Also being presented are analyses from the DUOGLOBE study, a three-year global, multicenter, single-arm, non-interventional post-marketing observational study of patients with advanced PD treated with DUODOPA.
Additionally, abstracts demonstrating the prevalence, impact and economic burden of PD will be presented.