Research targets the development of face masks and other products that inactivate viruses.
SALT LAKE CITY, Sept. 02, 2020 (GLOBE NEWSWIRE) -- SINTX Technologies, Inc. (NASDAQ:SINT) (“SINTX” or the “Company”), an original equipment manufacturer of silicon nitride ceramic for medical and non-medical applications, announced new studies confirming that its material inactivates SARS-CoV-2, the causative agent of the COVID-19 pandemic, as well as the Influenza A virus that is responsible for the common cold.
Previous findings had shown that SINTX’s silicon nitride can inactivate SARS-CoV-2, as well as other single-strand RNA (ssRNA) viruses such as Influenza A, Feline calicivirus, and Enterovirus. Those findings were first reported in June 2020 on BioRxiv, a pre-print server for COVID-19 research ahead of peer review. Data related to the other ssRNA viruses are under peer review for publication.
The latest SARS-CoV-2 testing was done at the National Center for Biodefense and Infectious Diseases, George Mason University, Virginia (GMU). The study was designed to (1) reproduce the earlier findings using an independent institution and study protocol, and (2) show a time-and dose-dependent antiviral effect of silicon nitride, and (3) establish a U.S.-based testing facility for future testing of commercial products, such as fabrics containing silicon nitride.
The GMU data confirm that silicon nitride strongly inhibits SARS-CoV-2, after just one minute of exposure. The anti-viral effect increases with higher doses and longer duration of exposure to silicon nitride. Importantly, silicon nitride is non-toxic to mammalian cells, a finding that is consistent with the successful clinical outcomes of SINTX’s spinal implants made of the same material as was tested at GMU.
Separate testing at another contract research facility, ImQuest BioSciences, Frederick Maryland, showed that SINTX’s silicon nitride strongly inactivates the Influenza A virus as well. Selected data from that testing is shown in the graph above.
“The ability of silicon nitride to effectively terminate the SARS-CoV-2 and Influenza A viruses is of importance, as the world braces for the flu season, with SARS-CoV-2 still around,” said Dr. Sonny Bal, President, and CEO of SINTX Technologies. “We are moving at full speed to incorporate silicon nitride into consumer masks that will catch-and-kill these respiratory pathogens. Beyond face masks, the antipathogenic advantages of silicon nitride will benefit schools, nursing homes, hospitals, casinos, cruise ships, day-care centers, commercial travel, and many other markets. Our R&D will advance the science, while external partners develop commercial products.”
“We are excited to get the results from this study as they solidify what we already know about SINTX and to continue efforts around bringing a mask to market,” said Bruce Lorange, CEO of O2TODAY, the company with whom SINTX has entered an agreement to develop face masks. “The latest data from SINTX is a solid confirmation of silicon nitride’s promise toward combatting the spread of COVID-19 and the flu, both of which are global worries.”
The COVID 19-driven demand for antipathogenic materials goes beyond face masks. As such, SINTX is identifying new revenue opportunities in industries such as automotive, aerospace, biomedicine, and others. The company is in discussions with prospective partners interested in developing a variety of products, such as automotive parts, cell phone cases, air filters, and medical PPE. SINTX looks forward to sharing additional developments in the coming months.