SOUTH SAN FRANCISCO, Calif., Aug. 18, 2020 (GLOBE NEWSWIRE) -- Cytokinetics, Incorporated (NASDAQ:CYTK) today announced a $1 million grant and four-year partnership with the HCM Registry (HCMR), a global registry of patients with hypertrophic cardiomyopathy (HCM) focused on improving predictive measures of risk for complications and identifying biomarkers associated with adverse clinical outcomes. The HCMR was designed as the first prospective multinational registry to identify novel prognostic markers in HCM, including CMR markers of fibrosis, genetic markers, and biomarkers. It has been funded to date by the National Heart, Lung, and Blood Institute, part of the National Institutes of Health (Grant number: U01 HL117006-01A1) and is being conducted by the University of Virginia and the University of Oxford. As an industry sponsor, Cytokinetics will join the HCMR Steering Committee in an observational capacity.
"We are pleased to partner with the HCM Registry to support better understandings of predictive risk factors for developing complications associated with living with HCM," said Fady I. Malik, M.D., Ph.D., Cytokinetics' Executive Vice President of Research & Development. "HCM can severely impact the daily lives of those diagnosed with the condition. Our long-term commitment to this important initiative is aligned with our dedication to outcomes research alongside our own drug development in the interests of patient-centric engagement and improved healthspan."
The HCMR is a prospective, observational study that enrolled 2,755 participants from 44 sites in six countries in North America and Europe who will be followed for at least five years and up to 10. Enrollment began in 2014 and completed in 2017. Primary outcome measures include cardiac death, aborted sudden cardiac death, heart transplant and left ventricular assist device placement. Secondary outcome measures include all-cause mortality, ventricular tachyarrhythmias, hospitalization for heart failure, atrial fibrillation and stroke. The results of the study will help predict the risk of developing complications associated with HCM and provide evidence to inform better treatment decisions. Additional information is available at www.clinicaltrials.gov/ct2/show/NCT01915615.