On June 26, 2020, Agile Therapeutics, Inc. established a wholesale acquisition cost of $159.75 for a treatment cycle of its TWIRLA® (levonorgestrel and ethinyl estradiol) transdermal system. Each TWIRLA treatment cycle is packaged in a carton containing three (3) individually pouched transdermal systems. TWIRLA is used in a 4-week (28 day) cycle. Patients apply 1 patch every week for 3 consecutive weeks, and each patch is worn for 7 days before being replaced by the next patch. No patch is worn during the fourth week.