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Corbus Pharmaceuticals Highlights Presentation Of Data Demonstrating ACR CRISS Score Reflects Patient-Reported Outcomes At 6th Systemic Sclerosis World E-Congress

Phase 2 systemic sclerosis (SSc) analyses show ACR CRISS score correlates with improvements from baseline in how patients feel and function through two years in the lenabasum Phase 2 open-label extension study ACR

Benzinga · -
  • Phase 2 systemic sclerosis (SSc) analyses show ACR CRISS score correlates with improvements from baseline in how patients feel and function through two years in the lenabasum Phase 2 open-label extension study

  • ACR CRISS score at Week 52 is the primary endpoint in the RESOLVE-1 Phase 3 study of lenabasum in SSc, with topline data on schedule for summer 2020
  • Satellite symposium will highlight role of the endocannabinoid system in chronic inflammation and fibrosis

Norwood, MA, June 29, 2020 (GLOBE NEWSWIRE) -- Corbus Pharmaceuticals Holdings, Inc. (NASDAQ:CRBP) (“Corbus” or the “Company”), a clinical-stage drug development company pioneering transformative medicines that target the endocannabinoid system, today announced the presentation of 3 abstracts at the 6th Systemic Sclerosis World E-Congress. The data presented in these abstracts show that the American College of Rheumatology Combined Response Index in diffuse cutaneous Systemic Sclerosis (ACR CRISS) score positively correlates with improvements in multiple patient-reported outcomes. Importantly, the ACR CRISS score also correlates more strongly with these patient-reported outcomes than change in modified Rodnan Skin Score (mRSS). Together, these data show that the ACR CRISS score broadly reflects changes from baseline in how patients feel and function.

These data will be presented in a recorded oral presentation and two e-posters at the 6th Systemic Sclerosis World E-Congress on June 29, 2020. Two live discussions sessions for the oral presentation will be held during the Live Congress on July 12, 2020 at 16:00-16:30 UCT+2 (Rome, Italy) time and on July 13, 2020 at 11:30-12:00 UCT+2 (Rome, Italy) time. All three abstracts will be published in the Journal of Scleroderma and Related Disorders.

In addition, the Company announced it will sponsor a satellite symposium titled “The Role of the Endocannabinoid System in Chronic Inflammation and Fibrosis” hosted by Professor Christopher Denton, MB, BS, PhD, FRCP, Head of Centre and Consultant Rheumatologist, University College London Division of Medicine, and Tracy Frech, M.D., MS, Director of the Systemic Sclerosis Clinic at the University of Utah Hospital and the Director of Clinical Trials for the Division of Rheumatology. The symposium will be held at the Live Congress on Sunday, July 12, 2020 at 14:30 UCT+2 (Rome, Italy) time. Once the presentation is made public, it will be available along with the three abstracts on the Company’s website in the Scientific Conferences section.

“These findings clearly demonstrate that ACR CRISS score reflects improvement in multiple measures of how SSc patients feel and function. This may be because the ACR CRISS score itself, unlike change in mRSS, incorporates 2 key patient-reported outcomes, the Health Assessment Questionnaire-Disability Index and the Patient Global Assessment of Health related to SSc. Our results support usefulness of using ACR CRISS score to evaluate clinical burden and benefit to patients in SSc trials,” said Barbara White, M.D., Chief Medical Officer and Head of Research of Corbus. “We remain on track to announce topline Phase 3 results using ACR CRISS score as the primary efficacy outcome later this summer.”