SPY302.97-0.56 -0.18%
DIA254.35-1.42 -0.56%
IXIC9,368.99-43.37 -0.46%

Oncocyte Highlights New Data Showing DetermaIO Gene Expression Test May Predict Response IN Immunotherapy In Triple Negative Breast Cancer At ASCO

Oncocyte Corporation (NYSE:OCX), a molecular diagnostics company with a mission to provide actionable answers at critical decision points across the cancer care continuum, today announced presentations at the 2020

Benzinga · 05/13/2020 22:08

Oncocyte Corporation (NYSE:OCX), a molecular diagnostics company with a mission to provide actionable answers at critical decision points across the cancer care continuum, today announced presentations at the 2020 American Society of Clinical Oncology (ASCO), being held virtually May 29-31, 2020.  

“Our studies being presented at ASCO highlight Oncocyte’s focus on providing high-value tests to patients across the cancer care continuum,” said Ron Andrews, Chief Executive Officer of Oncocyte. “While our focus on lung cancer remains strong, we are thrilled to present data today demonstrating the potential additional utility of DetermaIO™ in triple negative breast cancer, the deadliest form of breast cancer, potentially giving us the ability to help a population of patients for whom it is critical to rapidly choose the most effective treatment regimen.

Additionally, the health economic data show that the use of DetermaRx™ could potentially save the healthcare system millions of dollars. With the recent Medicare final local coverage decision for DetermaRx, we’re looking forward to making this test more widely accessible to physicians and patients in the coming months.”

Details on Oncocyte’s DetermaIO presentation at ASCO:

Title: Validation of an Immunomodulatory Gene Signature Algorithm to Predict Response to Neoadjuvant Immunochemotherapy in Patients with Primary Triple-Negative Breast Cancer
Session: Developmental Therapeutics – Immunotherapy
Presenter: Toshiaki Iwase, M.D., Ph.D., Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center
Date: Available on demand beginning May 29 at 8:00 a.m. EDT

The presentation details a validation of the association of DetermaIO, Oncocyte’s novel tumor microenvironment classifier with response to checkpoint inhibitor therapy in triple negative breast cancer (TNBC). The test measures expression of 27 genes from the tumor microenvironment and uses a proprietary algorithm to classify patients as likely responders or non-responders. The response of fifty-five patients with stage I-III primary TNBC to neoadjuvant immunotherapy (durvalumab with weekly nab-paclitaxel followed by ddAC), showed that DetermaIO was strongly associated with response whereas the standard of care test, PDL-1 IHC was not significant. The study was conducted in collaboration with multiple leading academic institutions, including the University of Texas MD Anderson Cancer Center, Yale University and the Baylor College of Medicine. The performance in TNBC in addition to the performance shown previously in NSCLC suggests its potential applicability across several types and stages of cancer of whom approximately 750,000 are eligible for treatment with checkpoint inhibitors.

Details on Oncocyte’s DetermaRx abstract:

The abstract, entitled “The potential of CLIA-certified prognostic/predictive molecular test (DetermaRx) to address the rising costs of non-small cell lung cancer” and published on the ASCO website, highlights the potential economic impact of DetermaRx. Health economic modeling showed that the test could result in significant health economic savings. The findings suggest that an increase in 25% disease free survival (DFS) potentially achieved through DetermaRx-directed adjuvant chemotherapy treatment would result in an average cost savings of $11,608 per patient and total potential systems savings of around $450 million. Current published data, which demonstrate a >45% reduction in DFS in treated high risk patients from use of DetermaRx, show that impact could be even higher and should make the test economically attractive to health systems, patients and commercial payers.