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AstraZeneca Highlights Data For TAGRISSO, ENHERTU To Be Presented At ASCO

AstraZeneca will present ground-breaking new results across its broad portfolio of cancer medicines during the 2020 American Society of Clinical Oncology ASCO20 Virtual Scientific Program, May 29 to May 31, 2020.

Benzinga · 05/13/2020 21:26

AstraZeneca will present ground-breaking new results across its broad portfolio of cancer medicines during the 2020 American Society of Clinical Oncology ASCO20 Virtual Scientific Program, May 29 to May 31, 2020. AstraZeneca will present 98 abstracts, including 19 oral presentations with one plenary and 10 late-breakers.

Presentations will showcase the Company’s leadership in the treatment of early lung cancer with a late-breaking plenary presentation of the unprecedented results from the Phase III ADAURA trial for TAGRISSO® (osimertinib) in the adjuvant treatment of patients with Stage IB, II and IIIA epidermal growth factor receptor-mutated (EGFRm) non-small cell lung cancer (NSCLC). Data from the DESTINY program will highlight the transformative potential of ENHERTU® (trastuzumab deruxtecan) across HER2-driven tumors, including in lung, breast, gastric and colorectal cancers.

José Baselga, Executive Vice President, Oncology R&D, said: “AstraZeneca continues to deliver results with the goal of transforming clinical practice. Our science at ASCO this year shows the potential for treatment of early-stage EGFR-mutated lung cancer, where we aim to provide the hope of cure with TAGRISSO; to rewrite the rules on the treatment of patients with HER2-positive tumors with ENHERTU across a range of cancer settings; and to advance our next wave of pipeline medicines focused on treating patients earlier and overcoming resistance.”

Dave Fredrickson, Executive Vice President, Oncology Business Unit, said: “One constant throughout these uncertain times is our unwavering commitment to changing the practice of medicine for patients living with cancer. Our new oncology medicines TAGRISSO, IMFINZI, LYNPARZA, and ENHERTU are demonstrating incredible momentum at ASCO, building on their established benefits for patients by delivering powerful data in new settings and bending cancer survival curves. This year’s data at ASCO reinforce our belief that we can one day eliminate cancer as a cause of death.”

Leadership in lung cancer across stages of disease

As AstraZeneca continues to advance lung cancer research and development from early to late-stage settings, the Company will present new data for TAGRISSO, IMFINZI® (durvalumab), ENHERTU, and potential new medicine savolitinib. Beyond ADAURA, an oral presentation of the final analysis of the Phase III CASPIAN trial confirms the sustained, clinically meaningful overall survival (OS) benefit of IMFINZI for patients with extensive-stage small cell lung cancer (ES-SCLC). Another oral presentation reinforces the potential of ENHERTU for patients with HER2-mutant NSCLC (see below). Results from a Phase II trial of savolitinib in patients with mesenchymal-epithelial transition (MET) exon 14 skipping mutations will also be presented.

Transforming treatment across HER2-driven cancers

AstraZeneca, in collaboration with Daiichi Sankyo Company, Limited (Daiichi Sankyo) will present new data from several trials highlighting the transformative potential of ENHERTU, including detailed results from the Phase II DESTINY-Gastric01 trial which showed a statistically significant and clinically meaningful improvement in objective response rate and OS for patients with HER2-positive metastatic gastric cancer. ENHERTU was recently granted Breakthrough Therapy Designation in the US for patients in this setting. Phase II data will also be presented for HER2-positive colorectal cancer and HER2-mutant NSCLC, two cancer settings for which there are currently no approved HER2-targeted medicines. Additionally, subgroup analyses from the Phase II DESTINY-Breast01 trial will reinforce the durable and consistent responses seen with ENHERTU in HER2-positive metastatic breast cancer.

Advancing treatment in other cancer types with high unmet need

AstraZeneca will present data from several trials highlighting how the Company’s leading research is progressing treatment in other cancers where a high unmet medical need remains, including:

  • An oral presentation of results from Study 22 for the IMFINZI plus tremelimumab combination using a novel regimen in advanced liver cancer
  • Final OS results from the Phase III SOLO2 trial for LYNPARZA® (olaparib) maintenance treatment in patients with BRCA-mutated platinum-sensitive relapsed ovarian cancer in an oral presentation. LYNPARZA is developed and commercialized in collaboration with Merck & Co., Inc. (Merck: known as MSD outside the US and Canada)
  • Multiple trials underscoring the impressive profile of CALQUENCE®(acalabrutinib), including data from the Phase II ACE-CL-001 trial with more than four years of follow up. The presentations represent the most mature safety and efficacy data to date with CALQUENCE monotherapy in patients with chronic lymphocytic leukemiaa