Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced the company will share updates from its diverse clinical oncology portfolio at the 2020 American Society of Clinical Oncology (ASCO) Annual Meeting from May 29-31 taking place virtually.
Among the accepted abstracts are new, longer-term data for PD-1 inhibitor Libtayo® (cemiplimab-rwlc) in advanced cutaneous squamous cell carcinoma (CSCC). The data published today, which will be updated during ASCO, add to the most mature dataset for any therapy in advanced CSCC and show that median overall survival and median duration of response have yet to be reached for Libtayo-treated patients with no new safety signals observed. Additional abstracts outline the clinical trial designs for Regeneron's first costimulatory bispecific REGN5678 (PSMAxCD28) in metastatic castration-resistant prostate cancer and the company's first tumor-targeted bispecific REGN5093 (METxMET) in MET-altered advanced non-small cell lung cancer (NSCLC).
"Regeneron is committed to advancing an oncology program to potentially transform treatment paradigms across multiple solid tumors and blood cancers where there are significant unmet needs," said Israel Lowy, M.D., Senior Vice President, Translational and Clinical Sciences, Oncology at Regeneron. "We've already made significant progress. Libtayo is the standard of care for advanced cutaneous squamous cell carcinoma, and we recently announced clinically meaningful outcomes from our pivotal Libtayo trials in advanced non-small cell lung cancer and advanced basal cell carcinoma. At ASCO, we will build on these milestones with three-year data from Libtayo in advanced cutaneous squamous cell carcinoma and updates from our expanding bispecific antibody platform."
Investor Webcast Information
Regeneron will host a conference call and simultaneous webcast to share updates on Regeneron's oncology portfolio on Monday, June 1 at 4:30 pm ET. To access this call, dial (888) 660-6127 (U.S.) or (973) 890-8355 (International). A link to the webcast may be accessed from the "Investors and Media" page of Regeneron's website at www.regeneron.com. A replay of the conference call and webcast will be archived on the Company's website and will be available for at least 30 days.
Regeneron presentations and publications at ASCO
Libtayo (PD-1 inhibitor) & Skin Cancer (jointly presented and published with Sanofi)
- Phase 2 study of cemiplimab in patients (pts) with advanced cutaneous squamous cell carcinoma (CSCC): Longer follow-up (Abstract 10018, Poster 367; Danny Rischin, M.D.; Poster Discussion)
- Health-related quality of life (HRQL) in patients with advanced cutaneous squamous cell carcinoma (CSCC) treated with cemiplimab: Post hoc exploratory analysis of a Phase 2 clinical trial (Abstract 10033, Poster 382; Michael Migden, M.D.; Poster)
- Assessing the value of cemiplimab for adults with advanced cutaneous squamous cell carcinoma (CSCC): A cost-effectiveness analysis (Abstract e19397; Eleanor Paul; Online Publication)
- A Phase 3, randomized, double-blind study of adjuvant cemiplimab versus placebo post-surgery and radiation therapy (RT) in patients (pts) with high-risk cutaneous squamous cell carcinoma (CSCC) (Abstract TPS10084, Poster 433; Danny Rischin, M.D.; Trial in Progress Poster)
- Patterns of hedgehog inhibitor (HHI) treatment interruptions and re-initiations among patients with basal cell carcinoma (BCC) in real-world clinical practice (Abstract e19349; Jessica Jalbert, Ph.D.; Online Publication)
REGN5678 (PSMAxCD28 Costimulatory Bispecific)
- A Phase 1/2 study of REGN5678 (Anti-PSMAxCD28, a costimulatory bispecific antibody) with cemiplimab (anti-PD-1) in patients with metastatic castration-resistant prostate cancer (Abstract TPS5592, Poster 173; Charles Drake, M.D., Ph.D.; Trial in Progress Poster)
REGN5093 (METxMET Tumor-targeted Bispecific)
- A Phase 1/2 study of REGN5093, a METxMET bispecific antibody, in patients with MET-altered advanced non-small cell lung cancer (NSCLC) (Abstract TPS9628, Poster 394; Tracey Rowlands, Ph.D.; Trial in Progress Poster)
Diffuse Large B-Cell Lymphoma
- Real-world treatment patterns among patients with diffuse large B-cell lymphoma (DLBCL) treated with CD19-directed chimeric antigen receptor T-cell therapy (CAR T) (Abstract e19351; Jessica Jalbert, Ph.D.; Online Publication)