VolitionRx Limited (NYSE:VNRX) ("Volition"), an epigenetics company developing simple, easy to use and cost effective blood tests to help diagnose a range of cancers, will present three abstracts at the 2020 ASCO Annual Meeting.
The first abstract presented announces initial data demonstrating the ability of Volition's sample-enrichment tool, Nu.Q™ Capture, to separate short and long nucleosomes in clinical colorectal cancer samples to enable the concentration of tumor-derived nucleosomal markers prior to analysis. The other two abstracts presented provide new performance data for Volition's Nucleosomics™ Nu.Q™ technology in the early detection of lung cancer and blood cancer.
E13534: Enrichment of circulating tumor DNA from cell free DNA of Hematopoietic origin
Data from this pilot study, the first published results for Volition's Nu.Q™ Capture program, showed that Nu.Q™ Capture technology successfully demonstrated enrichment of circulating tumor nucleosomes and tumor DNA ("ctDNA"). The data clearly showed the separation of short and long nucleosomes from both cancer cell lines in a laboratory setting, and in clinical colorectal cancer patients versus healthy controls.
Dr. Mark Eccleston, Business Development Director and a founding scientist at Volition, said: "Effective removal of most 'healthy/long' nucleosomes creates an enriched sample allowing for more accurate measurement of cancer nucleosomes. Similarly, the removal of most 'healthy/long' nucleosome-associated DNA can also enhance detection of cancer using ctDNA technologies. These data are a really positive sign of the potential of Nu.Q™ Capture as a valuable tool to enable improved and earlier detection of cancer."