Mersana Therapeutics, Inc. (NASDAQ:MRSN), a clinical-stage biopharmaceutical company focused on discovering and developing a pipeline of antibody-drug conjugates (ADCs) targeting cancers in areas of high unmet medical need, today announced that it will present interim data from the ongoing Phase 1 expansion evaluating XMT-1536, its first-in-class ADC candidate targeting NaPi2b, in patients with ovarian cancer and non-small cell lung (NSCLC) adenocarcinoma. The data will be presented in a poster session featuring study investigator, Debra L. Richardson, MD, Associate Professor of Gynecologic Oncology at the Stephenson Cancer Center at the University of Oklahoma Health Sciences Center and the Sarah Cannon Research Institute at the American Society of Clinical Oncology (ASCO) 2020 Virtual Scientific Program being held from May 29 – May 31, 2020.
Details of the poster session and accompanying summary presentation by Dr. Richardson are as follows:
Poster Title: Phase I expansion study of XMT-1536, a novel NaPi2b-targeting antibody-drug conjugate (ADC): Preliminary efficacy, safety, and biomarker results in patients with previously treated metastatic ovarian cancer (OC) or non-small cell lung cancer (NSCLC).
Abstract Number: 3549
Date: Friday, May 29, 2020
Poster Available: 8:00 a.m. ET
Session: Developmental Therapeutics— Molecularly Targeted Agents and Tumor Biology
The poster will include safety, tolerability and efficacy for new patients treated with 36 mg/m2 and 43 mg/m2. Further, these interim data will also report on the relationship between response and biomarker expression. With a cutoff of May 1, 2020, the ASCO presentation will include 20 RECIST-evaluable ovarian cancer patients and 4 RECIST-evaluable NSCLC patients. Biomarker expression data will be available for the majority of evaluable patients. Additional patients are enrolled in the study but have not yet reached the RECIST evaluation timepoint.